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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-5-4
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pubmed:abstractText |
Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We report the cloning and characterization of ephexin, a novel Eph receptor-interacting protein that is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Ephrin-A stimulation of EphA receptors modulates the activity of ephexin leading to RhoA activation, Cdc42 and Rac1 inhibition, and cell morphology changes. In addition, expression of a mutant form of ephexin in primary neurons interferes with ephrin-A-induced growth cone collapse. The association of ephexin with Eph receptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a novel mechanism for achieving highly localized regulation of growth cone motility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BazalakovaMM,
pubmed-author:CorfasGG,
pubmed-author:DebantAA,
pubmed-author:EstrachSS,
pubmed-author:GoldbergJ LJL,
pubmed-author:GreenbergM EME,
pubmed-author:IIAA,
pubmed-author:LimM YMY,
pubmed-author:NeveR LRL,
pubmed-author:SahinMM,
pubmed-author:ShandsR GRG
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11336673-Actins,
pubmed-meshheading:11336673-Amino Acid Sequence,
pubmed-meshheading:11336673-Animals,
pubmed-meshheading:11336673-Brain Chemistry,
pubmed-meshheading:11336673-Cells, Cultured,
pubmed-meshheading:11336673-Cloning, Molecular,
pubmed-meshheading:11336673-Embryo, Mammalian,
pubmed-meshheading:11336673-Ephrin-A1,
pubmed-meshheading:11336673-Eye,
pubmed-meshheading:11336673-Fetal Proteins,
pubmed-meshheading:11336673-Growth Cones,
pubmed-meshheading:11336673-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:11336673-Immunoblotting,
pubmed-meshheading:11336673-In Situ Hybridization,
pubmed-meshheading:11336673-Mice,
pubmed-meshheading:11336673-Molecular Sequence Data,
pubmed-meshheading:11336673-Nerve Tissue Proteins,
pubmed-meshheading:11336673-Phylogeny,
pubmed-meshheading:11336673-Protein Structure, Tertiary,
pubmed-meshheading:11336673-Proteins,
pubmed-meshheading:11336673-Rats,
pubmed-meshheading:11336673-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:11336673-Signal Transduction,
pubmed-meshheading:11336673-Two-Hybrid System Techniques,
pubmed-meshheading:11336673-rho GTP-Binding Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.
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pubmed:affiliation |
Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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