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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-4-13
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pubmed:abstractText |
Various natural and synthetic compounds including alkaloids, terpenoids and phenolics were tested for inhibition of the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), both of which are crucial in the regulation of immune response and inflammation. Of 40 compounds tested, two compounds significantly downregulated the expression of VCAM-1 on murine endothelial cells (F-2) and ten compounds that of ICAM-1 on mouse myeloid leukemia cells (M1). Sanguinarine chloride (5) and isoliquiritigenin (13) were capable of lowering the levels of both ICAM-1 and VCAM-1. The structure-activity relationships study on chalcone and flavone derivatives related to 13 suggested that the inhibitory activity of the chalcone derivatives is attributable to the 4-hydroxy group as well as the possible coplanarity between the phenyl ring and the adjacent conjugated ketone.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/Chalcone,
http://linkedlifedata.com/resource/pubmed/chemical/Chalcones,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/isoliquiritigenin,
http://linkedlifedata.com/resource/pubmed/chemical/sanguinarine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0032-0943
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pubmed:author |
pubmed-author:HondaGG,
pubmed-author:IkeshiroYY,
pubmed-author:KamisakoWW,
pubmed-author:KashiwadaYY,
pubmed-author:MasudaTT,
pubmed-author:MorimotoKK,
pubmed-author:NagakuraNN,
pubmed-author:OshimaTT,
pubmed-author:SakataYY,
pubmed-author:ShimadaMM,
pubmed-author:TabataMM,
pubmed-author:TambsKK,
pubmed-author:TanakaSS,
pubmed-author:UmezawaTT,
pubmed-author:WatanabeYY
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
108-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11301853-Alkaloids,
pubmed-meshheading:11301853-Animals,
pubmed-meshheading:11301853-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11301853-Benzophenanthridines,
pubmed-meshheading:11301853-Chalcone,
pubmed-meshheading:11301853-Chalcones,
pubmed-meshheading:11301853-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11301853-Isoquinolines,
pubmed-meshheading:11301853-Mice,
pubmed-meshheading:11301853-Mice, Inbred Strains,
pubmed-meshheading:11301853-Molecular Structure,
pubmed-meshheading:11301853-Phenols,
pubmed-meshheading:11301853-Plants, Medicinal,
pubmed-meshheading:11301853-Structure-Activity Relationship,
pubmed-meshheading:11301853-Terpenes,
pubmed-meshheading:11301853-Tumor Cells, Cultured,
pubmed-meshheading:11301853-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2001
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pubmed:articleTitle |
Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1.
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pubmed:affiliation |
Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan. stanaka@nodai.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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