Linked Life Data

11200281

Source:http://linkedlifedata.com/resource/pubmed/id/11200281

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10-12
pubmed:dateCreated
2001-1-25
pubmed:abstractText
Aryl or tert-butyl substituent in the 6 position of 3,9-dihydro-3-[(2-hydroxyethoxy)methyl]-9-oxo-6-R-5H-imidazo[1,2-a]purine (6-R-TACV) 1 partly directs aralkylation reactions into unusual positions: N-4 to give 3 and C-7 to give N-5,7-disubstituted or N-4,7-disubstituted derivatives. In the case of alkylation the effect is limited to aryl substituent and position N-4. Replacement of acyclic moiety of 1 with a ribosyl one like in 7 prevents N-4 substitution. Cleavage of the third ring of 3b to give 3-benzylacyclovir 10 is an example of a new short route to 3-aralkyl-9-substituted guanines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1911-29
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Substituent--directed aralkylation and alkylation reactions of the tricyclic analogues of acyclovir and guanosine.
pubmed:affiliation
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't