| pubmed-article:11120849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0039341 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C1413189 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0162825 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11120849 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11120849 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11120849 | pubmed:dateCreated | 2000-12-21 | lld:pubmed |
| pubmed-article:11120849 | pubmed:abstractText | Human basophils and mast cells express the chemokine receptor CCR3, which binds the chemokines eotaxin and RANTES. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells obtained from healthy individuals seronegative for Abs to HIV-1 and HIV-2. Tat protein induced a rapid and transient Ca(2+) influx in basophils and mast cells, analogous to beta-chemokines. Tat protein neither induced histamine release from human basophils and mast cells nor increased IL-3-stimulated histamine secretion from basophils. The chemotactic activity of Tat protein was blocked by preincubation of FcepsilonRI(+) cells with anti-CCR3 Ab. Preincubation of Tat with a mAb anti-Tat (aa 1-86) blocked the migration induced by Tat. In contrast, a mAb specific for the basic region (aa 46-60) did not inhibit the chemotactic effect of Tat protein. Tat protein or eotaxin desensitized basophils to a subsequent challenge with the autologous or the heterologous stimulus. Preincubation of basophils with Tat protein up-regulated the level of CCR3 mRNA and the surface expression of the CCR3 receptor. Tat protein is the first identified HIV-1-encoded beta-chemokine homologue that influences the directional migration of human FcepsilonRI(+) cells and the expression of surface receptor CCR3 on these cells. | lld:pubmed |
| pubmed-article:11120849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11120849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11120849 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11120849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11120849 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11120849 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:MaroneGG | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:AccollaR SRS | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:TosoAA | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:de PaulisAA | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:De PalmaRR | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:CarforaMM | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:Di GioiaLL | lld:pubmed |
| pubmed-article:11120849 | pubmed:author | pubmed-author:PreveteNN | lld:pubmed |
| pubmed-article:11120849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11120849 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11120849 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:11120849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11120849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11120849 | pubmed:pagination | 7171-9 | lld:pubmed |
| pubmed-article:11120849 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11120849 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11120849 | pubmed:articleTitle | Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc epsilon RI+ cells. | lld:pubmed |
| pubmed-article:11120849 | pubmed:affiliation | Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy. | lld:pubmed |
| pubmed-article:11120849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11120849 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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