Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-1232
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| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat binds to CCR3 and displaces MCP-3 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51,
HIV-1 Tat upregulates CCR3 expression on monocytes/macrophages, Fc epsilonRI+ cells and blood brain barrier cultures, and acts as a potent chemoattractant, indicating a role for Tat in HIV-1 pathogenesis and in promoting HIV-1 infectivity,
HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and 3-integrin expression on platelets and calcium flux in platelets,
HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the -chemokine receptor CCR-3
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| entrezgene:keyphrase |
cooperates with,
upregulates,
binds,
modulates
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