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rdf:type |
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lifeskim:mentions |
umls-concept:C0006837,
umls-concept:C0017262,
umls-concept:C0030946,
umls-concept:C0031678,
umls-concept:C0031727,
umls-concept:C0035143,
umls-concept:C0185117,
umls-concept:C0332291,
umls-concept:C0752312,
umls-concept:C1979930,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
2000-12-13
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pubmed:abstractText |
Cpp1p is a putative mitogen-activated protein (MAP) kinase phosphatase that suppresses Candida albicans hyphal formation at 25 degrees C through its probable substrate, the Cek1p filamentation MAP kinase. Here we report that expression of the serum-induced genes SAP4-6 and HYR1 increased several fold in hyphal forms of a cpp1/cpp1 null mutant, while the rate and extent of hyphal development up to 5 h were normal. Therefore, we provide evidence that Cpp1p represses hyphal gene expression by acting through a Cek1p-independent mechanism. SAP4-6 and HYR1 transcripts were undetectable in a null mutant of another key regulator of filamentation, Efg1p; thus, Efg1p and Cpp1p oppose each other during the expression of these genes in hyphal forms.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-10464197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-10496941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-10652099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-6394964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-7523825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-7854319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-7891715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-7992058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-8808922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-8917571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-8917572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9155024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9259554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9284117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9298905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9398674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083847-9890266
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/CEK1 protein, Candida albicans,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EFG1 protein, Candida albicans,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HYR1 protein, Candida albicans,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SAP4 protein, Candida albicans,
http://linkedlifedata.com/resource/pubmed/chemical/SAP5 protein, Candida albicans,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7159-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11083847-Aspartic Acid Endopeptidases,
pubmed-meshheading:11083847-Candida albicans,
pubmed-meshheading:11083847-DNA-Binding Proteins,
pubmed-meshheading:11083847-Fungal Proteins,
pubmed-meshheading:11083847-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:11083847-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11083847-Protein Tyrosine Phosphatases,
pubmed-meshheading:11083847-RNA, Messenger,
pubmed-meshheading:11083847-Repressor Proteins,
pubmed-meshheading:11083847-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.
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pubmed:affiliation |
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, 91054 Erlangen, Germany. klaus.schroeppel@mikrobio.med.unierlangen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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