Source:http://linkedlifedata.com/resource/pubmed/id/10930990
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-9-13
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pubmed:abstractText |
Elevated plasminogen activator inhibitor 1 (PAI-1) levels are associated with venous thromboembolism, although their significance is unclear. PAI-1 levels are influenced by a PAI-1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI-1 activity. We investigated whether the 4G allele influenced thrombotic risk by studying 99 symptomatic factor V (FV) Leiden heterozygotes and 99 healthy subjects. The 4G allele was more prevalent among cases than among healthy subjects (chi2 = 8.00, P = 0.005) and the odds ratio (OR) for thrombosis associated with either heterozygosity or homozygosity for the 4G allele was 2.43 (P = 0. 011). We conclude that carriership of the 4G allele was more prevalent in patients who already carried factor V Leiden than in control subjects without factor V Leiden.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10930990-Adult,
pubmed-meshheading:10930990-Age of Onset,
pubmed-meshheading:10930990-Aged,
pubmed-meshheading:10930990-Alleles,
pubmed-meshheading:10930990-Case-Control Studies,
pubmed-meshheading:10930990-Chi-Square Distribution,
pubmed-meshheading:10930990-Confidence Intervals,
pubmed-meshheading:10930990-Factor V,
pubmed-meshheading:10930990-Female,
pubmed-meshheading:10930990-Genotype,
pubmed-meshheading:10930990-Humans,
pubmed-meshheading:10930990-Male,
pubmed-meshheading:10930990-Middle Aged,
pubmed-meshheading:10930990-Odds Ratio,
pubmed-meshheading:10930990-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:10930990-Polymorphism, Genetic,
pubmed-meshheading:10930990-Risk,
pubmed-meshheading:10930990-Thrombophilia
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pubmed:year |
2000
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pubmed:articleTitle |
Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden.
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pubmed:affiliation |
Division of Molecular and Genetic Medicine, University of Sheffield Faculty of Medicine, Royal Hallamshire Hospital, Sheffield, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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