Linked Life Data

10924728

Source:http://linkedlifedata.com/resource/pubmed/id/10924728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-11-13
pubmed:abstractText
Mean high-density lipoprotein cholesterol (HDL-C) concentrations are low in the Jewish population of Israel. With this in mind we assessed the association of the Taq1B CETP polymorphism, plasma CETP mass and plasma lipid, lipoprotein and apolipoprotein concentrations in a sample of 884 Jerusalem residents aged 28-32. The allele frequency (0.435 +/- 0.017(S.E.)) is similar to that reported elsewhere. There was a strong (apparently codominant) association of the Taq1 B allele with plasma CETP in both sexes, and an inverse association with HDL-C and apo A-1, significant in women and undiminished upon adjustment for plasma CETP. There was evidence in this population for an admixture of two plasma CETP distributions, with 9% belonging to a distribution with the higher mean, pointing to a possible major gene effect. Mean plasma CETP was higher in women than men. Plasma CETP was inversely associated with HDL-C in men but not in women (P< 0.05 for the sex difference, multivariate analysis), inversely related to the HDL-C/apo A-1 ratio in men and positively related in women (P < 0.005 for the sex difference), and was positively associated with total cholesterol (TC) and low-density lipoprotein cholesterol in both sexes, and with the TC/HDL-C ratio and apo B in men alone. The sex differences may reflect dissimilarities in the regulatory function of CETP in lipid exchange. The absence of an unusual allele frequency of the Taq1B CETP polymorphism and its relatively modest association with HDL-C argue against an important role for this or strongly linked sites in determining the low population levels of HDL-C in Israel.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
509-18
pubmed:dateRevised
2008-8-29
pubmed:meshHeading
pubmed-meshheading:10924728-Alleles, pubmed-meshheading:10924728-Apolipoproteins, pubmed-meshheading:10924728-Carrier Proteins, pubmed-meshheading:10924728-Cholesterol, HDL, pubmed-meshheading:10924728-Cholesterol Ester Transfer Proteins, pubmed-meshheading:10924728-Deoxyribonucleases, Type II Site-Specific, pubmed-meshheading:10924728-Female, pubmed-meshheading:10924728-Gene Frequency, pubmed-meshheading:10924728-Glycoproteins, pubmed-meshheading:10924728-Humans, pubmed-meshheading:10924728-Jews, pubmed-meshheading:10924728-Lipoproteins, pubmed-meshheading:10924728-Male, pubmed-meshheading:10924728-Polymorphism, Genetic, pubmed-meshheading:10924728-Polymorphism, Restriction Fragment Length, pubmed-meshheading:10924728-Sex Characteristics, pubmed-meshheading:10924728-Smoking, pubmed-meshheading:10924728-Triglycerides
pubmed:year
2000
pubmed:articleTitle
Taq1B CETP polymorphism, plasma CETP, lipoproteins, apolipoproteins and sex differences in a Jewish population sample characterized by low HDL-cholesterol.
pubmed:affiliation
Department of Social Medicine, Hadassah Medical Organization and Hebrew University-Hadassah School of Public Health and Community Medicine, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel. jeremy1@vms.huji.ac.il
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't