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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-31
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pubmed:abstractText |
HER2 overexpression is a marker of aggressive breast cancer. Tumors that overexpress HER2 induce endothelial cell retraction and endothelial destabilization. Because angiopoietin-2 (Ang-2) also destabilizes microvessels, we postulated that HER2 signaling upregulates Ang-2 as a mechanism of angioinvasion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10922985-Angiopoietin-2,
pubmed-meshheading:10922985-Breast Neoplasms,
pubmed-meshheading:10922985-Enzyme Inhibitors,
pubmed-meshheading:10922985-Female,
pubmed-meshheading:10922985-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10922985-Genes, erbB-2,
pubmed-meshheading:10922985-Humans,
pubmed-meshheading:10922985-Proteins,
pubmed-meshheading:10922985-RNA, Messenger,
pubmed-meshheading:10922985-Receptor, erbB-2,
pubmed-meshheading:10922985-Recombinant Proteins,
pubmed-meshheading:10922985-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10922985-Signal Transduction,
pubmed-meshheading:10922985-Transcription, Genetic,
pubmed-meshheading:10922985-Transfection,
pubmed-meshheading:10922985-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
HER2 regulatory control of angiopoietin-2 in breast cancer.
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pubmed:affiliation |
Department of Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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