Linked Life Data

10867041

Source:http://linkedlifedata.com/resource/pubmed/id/10867041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-8-1
pubmed:abstractText
In 1996, the U.S. Food and Drug Administration approved olestra, a fat substitute, for use in snack foods. Previous studies had shown that olestra consumption could reduce absorption of carotenoids and fat-soluble vitamins. To determine the association between consumption of olestra-containing snack foods and serum concentrations of carotenoids and fat-soluble vitamins in a free-living population, we interviewed independent population-based cross-sectional samples of 1043 adults before olestra was available and 933 adults 9 mo after olestra snacks were introduced into the marketplace in Marion County, IN, the first major test market for olestra. A cohort composed of 403 adults from the first survey, oversampling those most frequently reporting olestra consumption during follow-up telephone interviews, completed a second survey. We assessed diet, lifestyle factors and olestra consumption, and collected blood for assays for the serum concentrations of six carotenoids, four fat-soluble vitamins and lipids. Nine months after the introduction of olestra into the marketplace, 15.5% of Marion County residents reported consuming an olestra-containing snack in the previous month, with a median frequency among consumers of 3.0 times per month. There were no significant associations or consistent trends for decreased serum carotenoids or fat-soluble vitamins associated with olestra consumption, although cohort members consuming >/=2 g/d of olestra had adjusted total serum carotenoids 15% lower compared with baseline. There were increases in serum vitamin K concentrations associated with olestra consumption (P = 0.03 in the cross section and P = 0.06 in the cohort). In summary, there was no statistically significant evidence in this free-living population of associations between olestra consumption and decreased serum concentrations of carotenoids and fat-soluble vitamins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1711-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10867041-Adolescent, pubmed-meshheading:10867041-Adult, pubmed-meshheading:10867041-African Continental Ancestry Group, pubmed-meshheading:10867041-Carotenoids, pubmed-meshheading:10867041-Cohort Studies, pubmed-meshheading:10867041-Cross-Sectional Studies, pubmed-meshheading:10867041-Dietary Fats, Unsaturated, pubmed-meshheading:10867041-European Continental Ancestry Group, pubmed-meshheading:10867041-Fat Substitutes, pubmed-meshheading:10867041-Fats, pubmed-meshheading:10867041-Fatty Acids, pubmed-meshheading:10867041-Female, pubmed-meshheading:10867041-Humans, pubmed-meshheading:10867041-Male, pubmed-meshheading:10867041-Middle Aged, pubmed-meshheading:10867041-Nutritional Status, pubmed-meshheading:10867041-Product Surveillance, Postmarketing, pubmed-meshheading:10867041-Solubility, pubmed-meshheading:10867041-Sucrose, pubmed-meshheading:10867041-Vitamin A, pubmed-meshheading:10867041-Vitamin D, pubmed-meshheading:10867041-Vitamin E, pubmed-meshheading:10867041-Vitamin K, pubmed-meshheading:10867041-Vitamins
pubmed:year
2000
pubmed:articleTitle
Olestra consumption does not predict serum concentrations of carotenoids and fat-soluble vitamins in free-living humans: early results from the sentinel site of the olestra post-marketing surveillance study.
pubmed:affiliation
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't