Source:http://linkedlifedata.com/resource/pubmed/id/10837922
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-8-11
|
| pubmed:abstractText |
The present study examines N-myc and c-myc protein expression with Western blotting and single and double-labeling immunohistochemistry in the hippocampus in Alzheimer disease (AD), the striatum in Huntington disease (HD) and the substantia nigra in Parkinson disease (PD). No modifications in the N-myc and c-myc expression are found in hippocampal neurons in AD, striatal neurons in HD, and pigmented neurons of the substantia nigra in PD. Yet punctate synaptic-like N-myc immunoreactivity, matching enhanced synaptophysin expression, occurs in diffuse plaques, but not in dystrophic neurites of neuritic plaques. In contrast, c-myc immunoreactivity is found in dystrophic neurites, but not in aberrant sproutings of neuritic plaques, as shown by double-labeling immunohistochemistry to c-myc and phosphorylated tau or phosphorylated neurofilament epitopes, and to c-myc and GAP-43, respectively. Strong N-myc and c-myc are observed in reactive astrocytes in AD, HD and PD, as revealed by double-labeling with N-myc or c-myc and GFAP. Finally, no relationship is found between nuclear DNA fragmentation and increased N-myc or c-myc expression in individual cells. These results demonstrate that neuron death in AD, HD and PD is not associated with modifications in the steady-state expression of N-myc and c-myc in individual neurons, and that neurofibrillary degeneration and Lewy body formation are not accompanied by increased immunoreactivity to these transcription factors. Increased N-myc and c-myc expression in reactive astrocytes probably plays a role in reactive astrocytosis in human neurodegenerative disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0169-328X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
77
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
270-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:10837922-Aged,
pubmed-meshheading:10837922-Aged, 80 and over,
pubmed-meshheading:10837922-Alzheimer Disease,
pubmed-meshheading:10837922-Astrocytes,
pubmed-meshheading:10837922-Blotting, Western,
pubmed-meshheading:10837922-Brain,
pubmed-meshheading:10837922-Cell Death,
pubmed-meshheading:10837922-DNA Fragmentation,
pubmed-meshheading:10837922-Female,
pubmed-meshheading:10837922-Gliosis,
pubmed-meshheading:10837922-Hippocampus,
pubmed-meshheading:10837922-Humans,
pubmed-meshheading:10837922-Huntington Disease,
pubmed-meshheading:10837922-Immunohistochemistry,
pubmed-meshheading:10837922-Male,
pubmed-meshheading:10837922-Neostriatum,
pubmed-meshheading:10837922-Parkinson Disease,
pubmed-meshheading:10837922-Plaque, Amyloid,
pubmed-meshheading:10837922-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:10837922-Substantia Nigra
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease.
|
| pubmed:affiliation |
Unitat de Neuropatologia, Servei d'Anatomia Patològica, Hospital Princeps d'Espanya, i Departament de Biologia Cel.lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Hospitalet de Llobregat, Llobregat, Spain. iferrer@sakma.es
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|