Linked Life Data

10834259

Source:http://linkedlifedata.com/resource/pubmed/id/10834259

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-6-28
pubmed:abstractText
The response of the kidney tissues to steroids, mainly dehydroepiandrosterone (DHEA), testosterone (T) and dihydrotestosterone (DHT) has been used extensively to investigate the mechanisms of steroid action on hypertension. The specific objective of this study was to investigate anatomical characteristics of kidney tissue after sustained delivery of DHEA, DHT or T at physiological or supraphysiological doses using adult male rats as a model. A total of eighteen adult male Sprague Dawley rats were divided randomly into six equal groups. Animals in groups I-V were implanted intraperitoneally with a single tricalcium phosphate lysine delivery system (TCPL) loaded with T (physiological dose), T (supraphysiological dose), DHT (physiological dose), DHT (supraphysiological dose), and DHEA (physiological dose), respectively. Animals in Group VI were implanted with empty TCPL capsules and served as sham controls. At the end of 21 days post implantation, the animals in each group were sacrificed and the kidneys were harvested, processed, embedded, sectioned and screened for cellular alterations. Data obtained from this study have shown physiological doses DHEA or supraphysiological doses of DHT and T had a significant effect on the areas of the glomeruli, without disruption or changes in area of proximal tubules. Histological evaluation of the organs (5 microns, H&E) revealed nephrotic hypotrophy in all kidneys obtained from animals given supraphysiological doses of DHT or T in comparison to sham animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0067-8856
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-6
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Morphological investigation of the rat kidney after continuous administration of testosterone, dihydrotestosterone, or dehydroepiandrosterone using TCPL delivery devices.
pubmed:affiliation
University of Saskatoon, Saschatawen Canada.
pubmed:publicationType
Journal Article