| pubmed-article:10772789 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C0243045 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1533107 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:10772789 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10772789 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10772789 | pubmed:dateCreated | 2000-5-31 | lld:pubmed |
| pubmed-article:10772789 | pubmed:abstractText | The pulse of ecdysone that triggers Drosophila metamorphosis activates six early genes in a primary response made visible by polytene chromosome puffs. The secondary response is detected by the induction of over 100 late puffs, only a few of which have been subject to molecular genetic analysis. We present a molecular and mutational analysis of the L63 gene responsible for the late puff at 63E. This gene contains overlapping L63A, B, and C transcription units of which the A unit encodes two isoforms and the B unit three. The C unit, which exhibits little activity, encodes one of the B isoforms. Evidence that L63B, but not L63A, transcription is ecdysone responsive derives from their developmental transcription profiles and from P-element mutagenesis showing that ecdysone induction of the 63E puff requires sequences adjacent to the 5' end of L63B but not those adjacent to the 5' end of L63A. L63-specific lethal mutations showed that L63 is required not only for metamorphosis, but also maternally and for embryonic and larval development. The L63 proteins contain a common C-terminal 294-aa sequence that is 71% identical to the CDK sequence of the murine PFTAIRE protein. In vivo tests of L63 proteins altered by site-directed mutagenesis showed that they exhibit CDK functions. L63 proteins are widely distributed among late larval and prepupal tissues and are unlikely to be involved in cell cycle functions. | lld:pubmed |
| pubmed-article:10772789 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10772789 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10772789 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10772789 | pubmed:month | May | lld:pubmed |
| pubmed-article:10772789 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:10772789 | pubmed:author | pubmed-author:HognessD SDS | lld:pubmed |
| pubmed-article:10772789 | pubmed:author | pubmed-author:GarzaDD | lld:pubmed |
| pubmed-article:10772789 | pubmed:author | pubmed-author:StowersR SRS | lld:pubmed |
| pubmed-article:10772789 | pubmed:author | pubmed-author:RascleAA | lld:pubmed |
| pubmed-article:10772789 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10772789 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10772789 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10772789 | pubmed:volume | 221 | lld:pubmed |
| pubmed-article:10772789 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10772789 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10772789 | pubmed:pagination | 23-40 | lld:pubmed |
| pubmed-article:10772789 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:meshHeading | pubmed-meshheading:10772789... | lld:pubmed |
| pubmed-article:10772789 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10772789 | pubmed:articleTitle | The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes CDK proteins required for Drosophila development. | lld:pubmed |
| pubmed-article:10772789 | pubmed:affiliation | Department of Biochemistry, Stanford University School of Medicine, Beckman Center, B300, Stanford, California 94305-5329, USA. | lld:pubmed |
| pubmed-article:10772789 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:34411 | entrezgene:pubmed | pubmed-article:10772789 | lld:entrezgene |
| entrez-gene:38432 | entrezgene:pubmed | pubmed-article:10772789 | lld:entrezgene |
| entrez-gene:38433 | entrezgene:pubmed | pubmed-article:10772789 | lld:entrezgene |
| entrez-gene:42453 | entrezgene:pubmed | pubmed-article:10772789 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10772789 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10772789 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10772789 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10772789 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10772789 | lld:pubmed |
