| pubmed-article:10727433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C1522670 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:10727433 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10727433 | pubmed:dateCreated | 2000-6-5 | lld:pubmed |
| pubmed-article:10727433 | pubmed:abstractText | Macrophage colony-stimulating factor (CSF-1) binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene and activates transcription of the urokinase plasminogen activator (uPA) gene in murine bone-marrow-derived macrophages. This article demonstrates that the murine macrophage cell line RAW264 responds to CSF-1 with inducible phosphorylation of cytoplasmic proteins on tyrosine residues but fails to induce transcription of uPA. The defect was correlated with a selective failure to maintain CSF-1Rs on the cell surface, whereas all RAW264 cells contained abundant CSF-1Rs within the presumptive Golgi/endoplasmic reticulum compartment. Transfection with a CSF-1R expression plasmid permitted CSF-1-dependent activation of the signalling pathway targeting an Ets/AP1 (activator protein 1) element in the uPA promoter that has been shown previously to be a target of oncogenic ras and protein kinase C pathways. Mutation of the expressed CSF-1R at either Y807 or Y559, sites of receptor tyrosine phosphorylation implicated in signal transduction, reduced but did not abolish uPA promoter activation by CSF-1. Activation by mutant CSF-1R plasmids was additive; there was no evidence of mutual complementation. The results indicate that maintenance of elevated uPA transcription by CSF-1 requires new receptors emerging continuously on the cell surface. Parallel, partly redundant, signalling pathways arising from phosphorylated tyrosines on the CSF-1R activate multiple cis-acting elements on the complex uPA promoter. | lld:pubmed |
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| pubmed-article:10727433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10727433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10727433 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10727433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10727433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10727433 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10727433 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:10727433 | pubmed:author | pubmed-author:HumeD ADA | lld:pubmed |
| pubmed-article:10727433 | pubmed:author | pubmed-author:HamiltonJ AJA | lld:pubmed |
| pubmed-article:10727433 | pubmed:author | pubmed-author:MarksDD | lld:pubmed |
| pubmed-article:10727433 | pubmed:author | pubmed-author:StaceyK JKJ | lld:pubmed |
| pubmed-article:10727433 | pubmed:author | pubmed-author:FowlesL FLF | lld:pubmed |
| pubmed-article:10727433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10727433 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10727433 | pubmed:volume | 347 Pt 1 | lld:pubmed |
| pubmed-article:10727433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10727433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10727433 | pubmed:pagination | 313-20 | lld:pubmed |
| pubmed-article:10727433 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10727433 | pubmed:meshHeading | pubmed-meshheading:10727433... | lld:pubmed |
| pubmed-article:10727433 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10727433 | pubmed:articleTitle | Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor. | lld:pubmed |
| pubmed-article:10727433 | pubmed:affiliation | Department of Biochemistry, Centre for Molecular and Cellular Biology, The University of Queensland, Q4072, Australia. | lld:pubmed |
| pubmed-article:10727433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10727433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10727433 | lld:pubmed |
