Source:http://linkedlifedata.com/resource/pubmed/id/10687308
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
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pubmed:dateCreated |
2000-4-13
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pubmed:abstractText |
The molecular basis of lymphoid organogenesis has recently been elucidated using gene-targeted mice. Mice deficient in lymphotoxin-alpha (LT alpha) lack lymph nodes and Peyer's patches. The action of LT alpha in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor I (TNFR-I) or II (TNFR-II). Additionally, follicular dendritic cell (FDC) clusters or germinal centers fail to develop in the spleen of LT alpha-deficient mice. Mice deficient in either TNFR-I or LT beta R also fail to develop splenic FDC clusters and germinal centers, indicating that signaling through both TNFR-I and LT beta R is required for the development of these structures. The mechanisms underlying the defective lymphoid organogenesis in LT alpha-deficient mice, together with a natural mutant strain, alymphoplasia (aly) mice, which manifest a quite similar phenotype to LT alpha-deficient mice, were investigated by generating aggregation chimeras. These studies demonstrate that LT alpha and the aly gene product together control lymphoid organogenesis with a close mechanistic relationship in their biochemical pathways through governing distinct cellular compartments; the former acting as a circulating ligand and the latter as a LT beta R-signaling molecule expressed by the stroma of the lymphoid organs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1343-1420
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10687308-Animals,
pubmed-meshheading:10687308-Antigens, CD,
pubmed-meshheading:10687308-Gene Targeting,
pubmed-meshheading:10687308-Ligands,
pubmed-meshheading:10687308-Lymphoid Tissue,
pubmed-meshheading:10687308-Lymphotoxin-alpha,
pubmed-meshheading:10687308-Mice,
pubmed-meshheading:10687308-Mice, Mutant Strains,
pubmed-meshheading:10687308-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10687308-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:10687308-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:10687308-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
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pubmed:affiliation |
Division of Informative Cytology, University of Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
Review
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