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pubmed-article:10637601pubmed:abstractTextMultidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.lld:pubmed
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pubmed-article:10637601pubmed:articleTitleMultiple physiological functions for multidrug transporter P-glycoprotein?lld:pubmed
pubmed-article:10637601pubmed:affiliationCellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia. r.johnstone@ari.unimelb.edu.aulld:pubmed
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