Source:http://linkedlifedata.com/resource/pubmed/id/10637601
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-3-2
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pubmed:abstractText |
Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0004
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10637601-Animals,
pubmed-meshheading:10637601-Biological Transport,
pubmed-meshheading:10637601-Cell Death,
pubmed-meshheading:10637601-Cell Differentiation,
pubmed-meshheading:10637601-Cholesterol,
pubmed-meshheading:10637601-Drug Resistance, Multiple,
pubmed-meshheading:10637601-Humans,
pubmed-meshheading:10637601-Lipid Metabolism,
pubmed-meshheading:10637601-P-Glycoprotein
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pubmed:year |
2000
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pubmed:articleTitle |
Multiple physiological functions for multidrug transporter P-glycoprotein?
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pubmed:affiliation |
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia. r.johnstone@ari.unimelb.edu.au
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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