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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-1-20
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pubmed:abstractText |
The glycoprotein recognized by the monoclonal antibody (mAb) 17-1A is present on most carcinomas, which makes it an attractive target for immunotherapy. Indeed, adjuvant treatment with mAb 17-1A did successfully reduce the 5 years mortality among colorectal cancer patients with minimal residual disease. Currently the antibody is approved for clinical use in Germany, and is on its way to approval in a number of other countries. New immunotherapeutic strategies targeting the 17-1A antigen are in development or even in early-phase clinical trials. Therefore, a better understanding of the biology of the 17-1A antigen may result in improved strategies for the treatment and diagnosis of human carcinomas. In this review the properties of the 17-1A antigen are discussed concerning tumor biology and the function of the molecule. This 40-kDa glycoprotein functions as an Epithelial Cell Adhesion Molecule, therefore the name Ep-CAM was suggested. Ep-CAM mediates Ca2+-independent homotypic cell-cell adhesions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Indeed, in vivo expression of Ep-CAM is related to increased epithelial proliferation and negatively correlates with cell differentiation. A regulatory function of Ep-CAM in the morphogenesis of epithelial tissue has been demonstrated for a number of tissues, in particular pancreas and mammary gland. The function of Ep-CAM should be taken into consideration when developing new therapeutic approaches targeting this molecule.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0946-2716
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-712
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pubmed:dateRevised |
2011-7-8
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pubmed:meshHeading |
pubmed-meshheading:10606205-Adult,
pubmed-meshheading:10606205-Animals,
pubmed-meshheading:10606205-Antibodies, Monoclonal,
pubmed-meshheading:10606205-Antigens, Neoplasm,
pubmed-meshheading:10606205-Breast,
pubmed-meshheading:10606205-Cadherins,
pubmed-meshheading:10606205-Carcinoma,
pubmed-meshheading:10606205-Cell Adhesion,
pubmed-meshheading:10606205-Cell Adhesion Molecules,
pubmed-meshheading:10606205-Cell Differentiation,
pubmed-meshheading:10606205-Cell Transformation, Neoplastic,
pubmed-meshheading:10606205-Chromosomes, Human, Pair 4,
pubmed-meshheading:10606205-Epithelial Cells,
pubmed-meshheading:10606205-Evolution, Molecular,
pubmed-meshheading:10606205-Female,
pubmed-meshheading:10606205-Fetal Proteins,
pubmed-meshheading:10606205-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10606205-Genes,
pubmed-meshheading:10606205-Humans,
pubmed-meshheading:10606205-Immunohistochemistry,
pubmed-meshheading:10606205-Immunotherapy,
pubmed-meshheading:10606205-Male,
pubmed-meshheading:10606205-Mice,
pubmed-meshheading:10606205-Mice, Transgenic,
pubmed-meshheading:10606205-Morphogenesis,
pubmed-meshheading:10606205-Multigene Family,
pubmed-meshheading:10606205-Organ Specificity,
pubmed-meshheading:10606205-Pancreas,
pubmed-meshheading:10606205-Protein Conformation,
pubmed-meshheading:10606205-Protein Structure, Tertiary,
pubmed-meshheading:10606205-Tumor Markers, Biological
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pubmed:year |
1999
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pubmed:articleTitle |
The biology of the 17-1A antigen (Ep-CAM).
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pubmed:affiliation |
Department of Pathology, Leiden University Medical Center, The Netherlands.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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