Source:http://linkedlifedata.com/resource/pubmed/id/10482274
General Info
Affiliation
Taub Alzheimer's Disease Research Center, Staten Island, NY, USA.Abstract
Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.
PMID
10482274
Publication types
Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't