Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.

Source:http://linkedlifedata.com/resource/pubmed/id/10482274

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General Info

Authors

Mehta PD, Wisniewski HM, Jacobs DM, Manly J, Bell K, Mayeux R, Small SA, Merchant C, Stern Y, Tang MX

Affiliation

Taub Alzheimer's Disease Research Center, Staten Island, NY, USA.

Abstract

Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.

PMID
10482274

Publication types

Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't