Source:http://linkedlifedata.com/resource/umls/id/C0611285
NCI: Encoded by human APP Gene (APP Family), Amyloid Beta A4 Protein Precursor is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor for cell mobility, adhesion, and axonogenesis/synaptogenesis, APP variants inhibit Notch signaling, regulate copper homeostasis, bind lipoproteins, activate transcription, and enhance apoptosis via G(O) and JIP pathways. NPXY is required for binding protein PID domains, endocytosis, and BaSS sorting. APP defects cause Alzheimer's disease and cerebroarterial amyloidosis.