Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-6-7
pubmed:abstractText
Prostaglandin G and H synthases, or cyclooxygenases (COXs), catalyze the formation of prostaglandins (PGs). Whereas COX-1 is diffusely expressed in lymphoid cells in embryonic day 15.5 thymus, COX-2 expression is sparse, apparently limited to stromal cells. By contrast, COX-2 is predominant in a subset of medullary stromal cells in three- to five-week-old mice. The isozymes also differ in their contributions to lymphocyte development. Thus, experiments with selective COX-1 inhibitors in thymic lobes from normal and recombinase-activating gene-1 knockout mice support a role for this isoform in the transition from CD4(-)CD8(-) double-negative (DN) to CD4(+)CD8(+) double-positive (DP). Concordant data were obtained in COX-1 knockouts. Pharmacological inhibition and genetic deletion of COX-2, by contrast, support its role during early thymocyte proliferation and differentiation and, later, during maturation of the CD4 helper T-cell lineage. PGE2, but not other PGs, can rescue the effects of inhibition of either isoform, although it acts through distinct EP receptor subtypes. COX-dependent PG generation may represent a mechanism of thymic stromal support for T-cell development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-10201998, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1374102, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1413490, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1427984, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1496552, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1547488, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1716517, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1845802, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-1984445, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-2121375, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-2129901, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-2434247, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7560632, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7594454, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7594459, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7594605, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7631045, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7639969, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7693857, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7730616, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7806436, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7822781, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7836930, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7843254, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7872783, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7907905, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7910843, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7964472, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7973703, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7982722, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-7996488, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8226870, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8242755, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8365485, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8387091, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8521477, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8521478, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8581280, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8604222, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8777578, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8781269, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8855294, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8939885, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-8976187, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-9294142, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-9321932, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-9348303, http://linkedlifedata.com/resource/pubmed/commentcorrection/10330429-9463402
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, mouse
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1469-77
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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