Linked Life Data

10230798

Source:http://linkedlifedata.com/resource/pubmed/id/10230798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-5-19
pubmed:abstractText
Recruitment of the coactivator CBP by signal-regulated transcription factors and stimulation of CBP activity are key regulatory events in the induction of gene transcription following Ca2+ flux through ligand- and/or voltage-gated ion channels in hippocampal neurons. The mode of Ca2+ entry (L-type Ca2+ channels versus NMDA receptors) differentially controls the CBP recruitment step to CREB, providing a molecular basis for the observed Ca2+ channel type-dependent differences in gene expression. In contrast, activation of CBP is triggered irrespective of the route of Ca2+ entry, as is activation of c-Jun, that recruits CBP independently of phosphorylation at major regulatory c-Jun phosphorylation sites, serines 63 and 73. This control of CBP recruitment and activation is likely relevant to other CBP-interacting transcription factors and represents a general mechanism through which Ca2+ signals associated with electrical activity may regulate the expression of many genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
789-98
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10230798-CREB-Binding Protein, pubmed-meshheading:10230798-Calcium, pubmed-meshheading:10230798-Calcium Channels, pubmed-meshheading:10230798-Cells, Cultured, pubmed-meshheading:10230798-Gene Expression Regulation, pubmed-meshheading:10230798-Hippocampus, pubmed-meshheading:10230798-Humans, pubmed-meshheading:10230798-Membrane Potentials, pubmed-meshheading:10230798-Nerve Tissue Proteins, pubmed-meshheading:10230798-Neurons, pubmed-meshheading:10230798-Nuclear Proteins, pubmed-meshheading:10230798-Phosphorylation, pubmed-meshheading:10230798-Proto-Oncogene Proteins c-fos, pubmed-meshheading:10230798-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:10230798-Recruitment, Neurophysiological, pubmed-meshheading:10230798-Trans-Activators, pubmed-meshheading:10230798-Transcriptional Activation
pubmed:year
1999
pubmed:articleTitle
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels.
pubmed:affiliation
Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't