| pubmed-article:10197586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C0144555 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C1335193 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C0035335 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C0598306 | lld:lifeskim |
| pubmed-article:10197586 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:10197586 | pubmed:issue | 7 Suppl | lld:pubmed |
| pubmed-article:10197586 | pubmed:dateCreated | 1999-4-22 | lld:pubmed |
| pubmed-article:10197586 | pubmed:abstractText | Pax-5 codes for the transcription factor BSAP, which plays an important role in midbrain patterning, B cell development, and lymphoma formation. Pax-5 is known to control gene expression by recognizing its target genes via the NH2-terminal paired domain and by regulating transcription through a COOH-terminal regulatory module consisting of activating and inhibitory sequences. The central region of Pax-5 contains a sequence with significant homology to the first alpha-helix of the paired-type homeodomain. This partial homeodomain has been highly conserved throughout vertebrate evolution because it is found not only in Pax-5 but also in the related Pax-2 and Pax-8 members of the same Pax subfamily. Here we report that the partial homeodomain binds the TATA-binding protein (TBP) and retinoblastoma (Rb) gene product. Both TBP and Rb were shown by coimmunoprecipitation experiments to directly associate with Pax-5 in vivo. The conserved core domain of TBP and the pocket region as well as COOH-terminal sequences of Rb are required for interaction with the partial homeodomain of Pax-5 in in vitro binding assays. Furthermore, Pax-5 was specifically bound only by the underphosphorylated form of Rb. These data indicate that Pax-5 is able to contact the basal transcription machinery through the TBP-containing initiation factor TFIID, and that its activity can be controlled by the cell cycle-regulated association with Rb. | lld:pubmed |
| pubmed-article:10197586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10197586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10197586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10197586 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10197586 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10197586 | pubmed:author | pubmed-author:BusslingerMM | lld:pubmed |
| pubmed-article:10197586 | pubmed:author | pubmed-author:EberhardDD | lld:pubmed |
| pubmed-article:10197586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10197586 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10197586 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:10197586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10197586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10197586 | pubmed:pagination | 1716s-1724s; discussion 1724s-1725s | lld:pubmed |
| pubmed-article:10197586 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:meshHeading | pubmed-meshheading:10197586... | lld:pubmed |
| pubmed-article:10197586 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10197586 | pubmed:articleTitle | The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. | lld:pubmed |
| pubmed-article:10197586 | pubmed:affiliation | Research Institute of Molecular Pathology, Vienna, Austria. | lld:pubmed |
| pubmed-article:10197586 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10197586 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5925 | entrezgene:pubmed | pubmed-article:10197586 | lld:entrezgene |
| entrez-gene:6908 | entrezgene:pubmed | pubmed-article:10197586 | lld:entrezgene |
| entrez-gene:5079 | entrezgene:pubmed | pubmed-article:10197586 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:10197586 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:10197586 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10197586 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10197586 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10197586 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10197586 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10197586 | lld:pubmed |
