Linked Life Data

9988347

Source:http://linkedlifedata.com/resource/pubmed/id/9988347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1999-3-24
pubmed:abstractText
The study assessed immunohistochemically the location and distribution of various non-collagenous matrix proteins (fibronectin, laminin, tenascin-C, osteocalcin, thrombospondin-1, vitronectin and undulin) in musculoskeletal tissues of rat. Fibronectin and thrombospondin-1 were found to be ubiquitous in the studied tissues. High immunoreactivity of these proteins was found in the extracellular matrix of the anatomical sites where firm bindings are needed, i.e. between muscle fibres and fibre bundles, between the collagen fibres of a tendon and at myotendinous junctions, osteotendinous junctions and articular cartilage. Tenascin-C was found in the extracellular matrix of regions where especially high forces are transmitted from one tissue component to the other, such as myotendinous junctions and osteotendinous junctions. Laminin was demonstrated in the basement membranes of the muscle cells and capillaries of the muscle-tendon units. Osteocalcin immunoreactivity concentrated in the extracellular matrix of areas of newly formed bone tissue, i.e. in the subperiosteal and subchondral regions, osteoid tissue and mineralized fibrocartilage zone of the osteotendinous junction. Mild vitronectin activity could be seen in the extracellular matrix of the osteotendinous and myotendinous junctions, and high activity around the bone marrow cells. Undulin could be demonstrated in the extracellular matrix (i.e. on the collagen fibres) of the tendon and epimysium only. However, it was co-distributed with fibronectin and tenascin-C. Together, these findings on the normal location and distribution of these non-collagenous proteins in the musculoskeletal tissues help to form the basis of knowledge against which the location and distribution of the these proteins in various pathological processes could be compared.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0018-2214
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
799-810
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9988347-Animals, pubmed-meshheading:9988347-Bone and Bones, pubmed-meshheading:9988347-Cartilage, Articular, pubmed-meshheading:9988347-Collagen, pubmed-meshheading:9988347-Extracellular Matrix Proteins, pubmed-meshheading:9988347-Fibronectins, pubmed-meshheading:9988347-Glycoproteins, pubmed-meshheading:9988347-Hindlimb, pubmed-meshheading:9988347-Immunohistochemistry, pubmed-meshheading:9988347-Laminin, pubmed-meshheading:9988347-Male, pubmed-meshheading:9988347-Muscle, Skeletal, pubmed-meshheading:9988347-Organ Specificity, pubmed-meshheading:9988347-Osteocalcin, pubmed-meshheading:9988347-Rats, pubmed-meshheading:9988347-Rats, Sprague-Dawley, pubmed-meshheading:9988347-Synovial Fluid, pubmed-meshheading:9988347-Tenascin, pubmed-meshheading:9988347-Tendons, pubmed-meshheading:9988347-Thrombospondin 1, pubmed-meshheading:9988347-Vitronectin
pubmed:year
1998
pubmed:articleTitle
Location and distribution of non-collagenous matrix proteins in musculoskeletal tissues of rat.
pubmed:affiliation
Accident and Trauma Research Center and Research Center of Sports Medicine, UKK Institute, Tampere, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't