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pubmed-article:9930396pubmed:abstractTextIn several animal species the pancreas has the capacity to partially regenerate in a self regulating process. A complex network of growth factors modulates this process. There is evidence that bombesin stimulates pancreatic regeneration in rodents. Whether bombesin stimulates pancreas regrowth in large mammals is unknown. Shc proteins, the target of tyrosine kinase-coupled receptors, activate p42 and p44 mitogen-activated protein (MAP) kinase and induce the transcriptional upregulation of genes involved in cell proliferation. The aims of our study were to determine whether bombesin stimulates pancreatic growth in large mammals and whether this event requires Shc-MAP kinase pathway upregulation.lld:pubmed
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pubmed-article:9930396pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:9930396pubmed:articleTitleBombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.lld:pubmed
pubmed-article:9930396pubmed:affiliationGastroenterology and Digestive Endoscopy Clinic, Dept. of General and Vascular Surgery, Università degli Studi di Perugia, Italy.lld:pubmed
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pubmed-article:9930396pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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