Linked Life Data

9930396

Source:http://linkedlifedata.com/resource/pubmed/id/9930396

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1999-3-23
pubmed:abstractText
In several animal species the pancreas has the capacity to partially regenerate in a self regulating process. A complex network of growth factors modulates this process. There is evidence that bombesin stimulates pancreatic regeneration in rodents. Whether bombesin stimulates pancreas regrowth in large mammals is unknown. Shc proteins, the target of tyrosine kinase-coupled receptors, activate p42 and p44 mitogen-activated protein (MAP) kinase and induce the transcriptional upregulation of genes involved in cell proliferation. The aims of our study were to determine whether bombesin stimulates pancreatic growth in large mammals and whether this event requires Shc-MAP kinase pathway upregulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1310-20
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9930396-Adaptor Proteins, Signal Transducing, pubmed-meshheading:9930396-Adaptor Proteins, Vesicular Transport, pubmed-meshheading:9930396-Animals, pubmed-meshheading:9930396-Bombesin, pubmed-meshheading:9930396-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9930396-Cells, Cultured, pubmed-meshheading:9930396-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:9930396-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:9930396-Mitogen-Activated Protein Kinases, pubmed-meshheading:9930396-Pancreas, pubmed-meshheading:9930396-Phosphorylation, pubmed-meshheading:9930396-Proteins, pubmed-meshheading:9930396-Regeneration, pubmed-meshheading:9930396-Shc Signaling Adaptor Proteins, pubmed-meshheading:9930396-Signal Transduction, pubmed-meshheading:9930396-Swine, pubmed-meshheading:9930396-Up-Regulation
pubmed:year
1998
pubmed:articleTitle
Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.
pubmed:affiliation
Gastroenterology and Digestive Endoscopy Clinic, Dept. of General and Vascular Surgery, Università degli Studi di Perugia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't