In this study, the role of intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of Pseudomonas aeruginosa keratitis was examined by using inbred ICAM-1-deficient knockout mice. These mice had significantly less (P </= 0.02) ocular disease than wild-type mice, suggesting that ICAM-1 contributes to a more severe disease response following P. aeruginosa infection.
Department of Anatomy and Cell Biology and Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. jhobden@med.wayne.edu
