Linked Life Data

9886376

Source:http://linkedlifedata.com/resource/pubmed/id/9886376

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pubmed-article:9886376pubmed:abstractTextWe have investigated the effects of IL-12 and cholera toxin (CT) on the immune response to tetanus toxoid (TT) given by intranasal or oral routes. CT inhibited IL-12-induced IFN-gamma secretion both in vivo and in vitro. Intranasal administration of IL-12 to mice nasally immunized with the combined vaccine of TT and CT resulted in increased TT-specific IgG2a and IgG3 Abs, while IgG1 and IgE Ab responses were markedly reduced. This shift of the CT-induced immune response toward Th1 type was associated with TT-specific CD4+ T cells secreting IFN-gamma and reduced levels of Th2-type cytokines (i.e., IL-4, IL-5, IL-6, and IL-10). In contrast, intranasal IL-12 enhanced the CT-induced serum IgG1 and IgE Ab responses in mice given the combined vaccine orally. IFN-gamma secretion by TT-specific CD4+ T cells was also enhanced; however, Th2-type cytokine responses were predominant. Mucosal secretory IgA responses to oral or nasal vaccines were not affected by intranasal IL-12. Thus, intranasal IL-12 delivery influences Th cell subset development in mucosal inductive sites that are dependent on the route of vaccine delivery.lld:pubmed
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pubmed-article:9886376pubmed:articleTitleUse of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin.lld:pubmed
pubmed-article:9886376pubmed:affiliationDepartment of Microbiology, Immunobiology Vaccine Center, University of Alabama Medical Center, Birmingham 35294-2170, USA.lld:pubmed
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pubmed-article:9886376pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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