Source:http://linkedlifedata.com/resource/umls/id/C0008356
MSH: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.,CSP: enterotoxin from Vibrio cholerae that consists of two major protomers, the heavy (h) or a subunit and the b protomer which consists of 5 light (l) or b subunits.,NCI: Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in