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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1999-1-28
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pubmed:abstractText |
Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H3 receptor antagonists.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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|
pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2157-62
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9873505-Animals,
pubmed-meshheading:9873505-Brain,
pubmed-meshheading:9873505-Cell Membrane,
pubmed-meshheading:9873505-Drug Design,
pubmed-meshheading:9873505-Guinea Pigs,
pubmed-meshheading:9873505-Histamine,
pubmed-meshheading:9873505-Histamine Antagonists,
pubmed-meshheading:9873505-Kinetics,
pubmed-meshheading:9873505-Molecular Structure,
pubmed-meshheading:9873505-Piperidines,
pubmed-meshheading:9873505-Receptors, Histamine H3,
pubmed-meshheading:9873505-Structure-Activity Relationship,
pubmed-meshheading:9873505-Sulfonamides
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pubmed:year |
1998
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pubmed:articleTitle |
Novel H3 receptor antagonists. Sulfonamide homologs of histamine.
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pubmed:affiliation |
Schering-Plough Research Institute, Department of Chemistry, Kenilworth, New Jersey 07033, USA.
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pubmed:publicationType |
Journal Article
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