Linked Life Data

986633

Source:http://linkedlifedata.com/resource/pubmed/id/986633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-10-29
pubmed:abstractText
The effects of application of GABA were studied in the closer and stretcher muscle of crayfish walking legs and compared to those on the opener muscle. EPSPs were measured intracellularly and extracellularly at single synaptic spots, and the input resistance of the muscle fiber was determined. In contrast to the opener muscle, in the closer and stretcher GABA receptors desensitized nearly completely within 5-10 min in the presence of GABA. The presynaptic receptors desensitized more slowly than the postsynaptic ones. While in the opener muscle betaguanidino propionic acid (betaGPA) activates only the presynaptic GABA receptors, in the closer and stretcher muscles both the pre- and the postsynaptic receptors are activated by betaGPA. The postsynaptic GABA receptor on the closer muscle desensitizes in the presence of betaGPA. The results show that with respect to desensitization and the effect of betaGPA four types of GABA receptors can be distinguished. As far as is known from the literature, the homologous synapses in lobster and crab can be assumed to have the same receptor types as those found in crayfish.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
364
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-22
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist.
pubmed:publicationType
Journal Article