| pubmed-article:9843489 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0040669 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0282629 | lld:lifeskim |
| pubmed-article:9843489 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9843489 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:9843489 | pubmed:dateCreated | 1999-2-11 | lld:pubmed |
| pubmed-article:9843489 | pubmed:abstractText | Peptides selected to bind to hepatitis B virus (HBV) core protein block interaction with the long viral surface antigen (L-HBsAg) in vitro. High resolution electron cryomicroscopy showed that one such peptide binds at the tips of the spikes of the core protein shell. The peptides contain two basic residues; changing either of two acidic residues at the spike tip to an alanine greatly reduced the binding affinity. Transfection of hepatoma cells with a replication-competent HBV plasmid gave significantly reduced production of virus in the presence of peptide, in a dose-dependent manner. These experiments show that the interaction of L-HBsAg with core particles is critical for HBV assembly, and give proof of principle for its disruption in vivo by small molecules. | lld:pubmed |
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| pubmed-article:9843489 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9843489 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9843489 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9843489 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9843489 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9843489 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:MurrayKK | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:TakahashiHH | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:BöttcherBB | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:TsujiNN | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:CrowtherR ARA | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:ZhaiYY | lld:pubmed |
| pubmed-article:9843489 | pubmed:author | pubmed-author:DysonM RMR | lld:pubmed |
| pubmed-article:9843489 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9843489 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9843489 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9843489 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9843489 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9843489 | pubmed:pagination | 6839-45 | lld:pubmed |
| pubmed-article:9843489 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9843489 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9843489 | pubmed:articleTitle | Peptides that block hepatitis B virus assembly: analysis by cryomicroscopy, mutagenesis and transfection. | lld:pubmed |
| pubmed-article:9843489 | pubmed:affiliation | Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. | lld:pubmed |
| pubmed-article:9843489 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9843489 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9843489 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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