Linked Life Data

9834623

Source:http://linkedlifedata.com/resource/pubmed/id/9834623

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-12-29
pubmed:abstractText
We established and characterized a novel experimental model of in vitro decidualization in normal human endometrial stromal cells. In a comparison of decidualization induction, 8-Br-cAMP showed the strongest ability to induce decidualization in stromal cells among four inducers examined: progesterone, medroxyprogesterone acetate, prostaglandin E2, and 8-Br-cAMP. The effects of 8-Br-cAMP were enhanced by prostaglandin E2 but not altered by medroxyprogesterone acetate. Both progesterone and medroxyprogesterone acetate activity was so weak that it took more than 2 weeks to induce in vitro decidualization. These results suggest that there are two independent decidualization signals in the in vitro decidualization, a cAMP-mediated signaling pathway and a progesterone receptor-mediated signaling pathway, and that cAMP-inducers are major factors in decidualization in vivo. Differential expressions of three membrane aminopeptidases on the stromal cells during the decidualization are also discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0030-6096
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Establishment and characterization of in vitro decidualization in normal human endometrial stromal cells.
pubmed:affiliation
Department of Obstetrics, Osaka City University Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't