Linked Life Data

9822758

Source:http://linkedlifedata.com/resource/pubmed/id/9822758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1998-12-18
pubmed:abstractText
Rats were given to drink an unfamiliar taste solution under conditions that result in long-term memory of that taste. The insular cortex, which contains the taste cortex, was then removed and assayed for activation of mitogen-activated protein kinase (MAPK) cascades by using antibodies to the activated forms of various MAPKs. Extracellular responsive kinase 1-2 (ERK1-2) in the cortical homogenate was significantly activated within <30 min of drinking the taste solution, without alteration in the total level of the ERK1-2 proteins. The activity subsided to basal levels within <60 min. In contrast, ERK1-2 was not activated when the taste was made familiar. The effect of the unfamiliar taste was specific to the insular cortex. Jun N-terminal kinase 1-2 (JNK1-2) was activated by drinking the taste but with a delayed time course, whereas the activity of Akt kinase and p38MAPK remained unchanged. Elk-1, a member of the ternary complex factor and an ERK/JNK downstream substrate, was activated with a time course similar to that of ERK1-2. Microinjection of a reversible inhibitor of MAPK/ERK kinase into the insular cortex shortly before exposure to the novel taste in a conditioned taste aversion training paradigm attenuated long-term taste aversion memory without significantly affecting short-term memory or the sensory, motor, and motivational faculties required to express long-term taste aversion memory. It was concluded that ERK and JNK are specifically and differentially activated in the insular cortex after exposure to a novel taste, and that this activation is required for consolidation of long-term taste memory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10037-44
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9822758-Animals, pubmed-meshheading:9822758-Behavior, Animal, pubmed-meshheading:9822758-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9822758-Cerebral Cortex, pubmed-meshheading:9822758-Conditioning (Psychology), pubmed-meshheading:9822758-Exploratory Behavior, pubmed-meshheading:9822758-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:9822758-Male, pubmed-meshheading:9822758-Memory, pubmed-meshheading:9822758-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:9822758-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:9822758-Mitogen-Activated Protein Kinase 9, pubmed-meshheading:9822758-Mitogen-Activated Protein Kinases, pubmed-meshheading:9822758-Protein Kinases, pubmed-meshheading:9822758-Rats, pubmed-meshheading:9822758-Rats, Wistar, pubmed-meshheading:9822758-Taste, pubmed-meshheading:9822758-p38 Mitogen-Activated Protein Kinases
pubmed:year
1998
pubmed:articleTitle
Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat.
pubmed:affiliation
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't