| pubmed-article:9817872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C0020017 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C0348801 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C2827666 | lld:lifeskim |
| pubmed-article:9817872 | lifeskim:mentions | umls-concept:C0441836 | lld:lifeskim |
| pubmed-article:9817872 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9817872 | pubmed:dateCreated | 1998-12-17 | lld:pubmed |
| pubmed-article:9817872 | pubmed:abstractText | Respiratory syncytial (RS) viruses isolated over three epidemic periods in a children's hospital in the United States were analyzed. The viruses (n = 174) were characterized as to major antigenic group (group A or B) by a PCR-based assay. Group A RS viruses were dominant the first 2 years, followed by a year with group B dominance (ratios of group A to group B viruses for epidemic periods, 56/4 for 1993-1994, 42/3 for 1994-1995, and 19/50 for 1995-1996). Genetic variability within the groups was assessed by restriction fragment analysis of PCR products; 79 isolates were also analyzed by nucleotide sequence determination of a variable region of the glycoprotein G gene. Among the group A RS virus isolates, this G-protein variable region had amino acid differences of as great as 38%. The G-protein amino acids of the group A viruses differed by up to 31% from the G-protein amino acids of a prototype (A2) group A virus. Among the group B RS virus G proteins, amino acid differences were as great as 14%. The G-protein amino acids of the group B viruses differed by up to 27% from the G-protein amino acids of a prototype (18537) group B virus. The group A and group B RS viruses demonstrated genetic variability between years and within individual years. Phylogenetic analysis revealed that there were multiple evolutionary lineages among both the group A and group B viruses. Among the recent group B isolates, variability was less than that seen for the group A viruses. However, comparisons to prototype strains revealed that the group B RS viruses may vary more extensively than was observed over the 3 years studied in the present investigation. | lld:pubmed |
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| pubmed-article:9817872 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9817872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9817872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9817872 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9817872 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:9817872 | pubmed:author | pubmed-author:SullenderW... | lld:pubmed |
| pubmed-article:9817872 | pubmed:author | pubmed-author:LefkowitzE... | lld:pubmed |
| pubmed-article:9817872 | pubmed:author | pubmed-author:CogginsW BWB | lld:pubmed |
| pubmed-article:9817872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9817872 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:9817872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9817872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9817872 | pubmed:pagination | 3552-7 | lld:pubmed |
| pubmed-article:9817872 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9817872 | pubmed:meshHeading | pubmed-meshheading:9817872-... | lld:pubmed |
| pubmed-article:9817872 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9817872 | pubmed:articleTitle | Genetic variability among group A and group B respiratory syncytial viruses in a children's hospital. | lld:pubmed |
| pubmed-article:9817872 | pubmed:affiliation | Departments of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA. | lld:pubmed |
| pubmed-article:9817872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9817872 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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