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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-12-17
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pubmed:abstractText |
Respiratory syncytial (RS) viruses isolated over three epidemic periods in a children's hospital in the United States were analyzed. The viruses (n = 174) were characterized as to major antigenic group (group A or B) by a PCR-based assay. Group A RS viruses were dominant the first 2 years, followed by a year with group B dominance (ratios of group A to group B viruses for epidemic periods, 56/4 for 1993-1994, 42/3 for 1994-1995, and 19/50 for 1995-1996). Genetic variability within the groups was assessed by restriction fragment analysis of PCR products; 79 isolates were also analyzed by nucleotide sequence determination of a variable region of the glycoprotein G gene. Among the group A RS virus isolates, this G-protein variable region had amino acid differences of as great as 38%. The G-protein amino acids of the group A viruses differed by up to 31% from the G-protein amino acids of a prototype (A2) group A virus. Among the group B RS virus G proteins, amino acid differences were as great as 14%. The G-protein amino acids of the group B viruses differed by up to 27% from the G-protein amino acids of a prototype (18537) group B virus. The group A and group B RS viruses demonstrated genetic variability between years and within individual years. Phylogenetic analysis revealed that there were multiple evolutionary lineages among both the group A and group B viruses. Among the recent group B isolates, variability was less than that seen for the group A viruses. However, comparisons to prototype strains revealed that the group B RS viruses may vary more extensively than was observed over the 3 years studied in the present investigation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1413992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1697126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1895054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1895391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1993875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-1995719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2010623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2230258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2294636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2378639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2413163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2441388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2525176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2579169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2723064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-2760479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-3305785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-3858865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-7707517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-8057427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-8099086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-8126162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9817872-9093944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3552-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
Genetic variability among group A and group B respiratory syncytial viruses in a children's hospital.
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pubmed:affiliation |
Departments of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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