Linked Life Data

9813148

Source:http://linkedlifedata.com/resource/pubmed/id/9813148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-12-10
pubmed:abstractText
Proper function of the protein tyrosine phosphatase CD45 is required for the positive regulation of the activity of src tyrosine kinases p56lck and p59fyn which participate in T-cell receptor and CD4 receptor signalling. In this study, the effect of HIV-1 infection on the function of CD45-associated tyrosine phosphatase activity in the H9 T-cell line has been investigated with respect to CD3 and CD4 ligation. A significant reduction in CD45-associated phosphatase activity was observed following CD3 + CD4 ligation in virally infected cells, whereas CD45 activity was not compromised following CD3 receptor ligation. Dysfunctional CD45 activity in infected cells was not attributable to reduced receptor surface expression induced by HIV-1, since CD4, CD3 and CD45 expression levels were found to be intact. Defective CD45 activity correlated with inhibted downstream signalling events as evidenced by reduced CD4-associated tyrosine kinase activity and inhibition of PLC-gamma1. Impaired CD45 function is likely to play a critical role in the inhibition of CD3/CD4 signalling thereby contributing to HIV-1 pathogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-291X
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Academic Press.
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-77
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Impaired CD45-associated tyrosine phosphatase activity during HIV-1 infection: implications for CD3 and CD4 receptor signalling.
pubmed:affiliation
Department of Immunology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London, EC1A 7BE, United Kingdom. christine_guntermann@macmailgw.dfci.harvard.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't