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rdf:type |
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lifeskim:mentions |
umls-concept:C0013879,
umls-concept:C0016030,
umls-concept:C0086860,
umls-concept:C0127082,
umls-concept:C0205108,
umls-concept:C0429403,
umls-concept:C0521447,
umls-concept:C1417708,
umls-concept:C1423613,
umls-concept:C1515877,
umls-concept:C1521761,
umls-concept:C1539081,
umls-concept:C1550315,
umls-concept:C1705525,
umls-concept:C1879547
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pubmed:issue |
11
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pubmed:dateCreated |
1998-11-20
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pubmed:abstractText |
To determine how interleukin-1 (IL-1), through activation of collagenase 1 (matrix metalloproteinase 1 [MMP-1]) transcription in synovial fibroblasts, contributes to cartilage degradation in rheumatoid arthritis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1987-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9811054-Animals,
pubmed-meshheading:9811054-Arthritis, Rheumatoid,
pubmed-meshheading:9811054-Base Sequence,
pubmed-meshheading:9811054-Binding Sites,
pubmed-meshheading:9811054-Cells, Cultured,
pubmed-meshheading:9811054-Collagenases,
pubmed-meshheading:9811054-Connective Tissue,
pubmed-meshheading:9811054-DNA-Binding Proteins,
pubmed-meshheading:9811054-Fibroblasts,
pubmed-meshheading:9811054-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9811054-Interleukin-1,
pubmed-meshheading:9811054-Matrix Metalloproteinase 1,
pubmed-meshheading:9811054-Molecular Sequence Data,
pubmed-meshheading:9811054-NF-kappa B,
pubmed-meshheading:9811054-Promoter Regions, Genetic,
pubmed-meshheading:9811054-Rabbits,
pubmed-meshheading:9811054-Synovial Membrane,
pubmed-meshheading:9811054-Transcription Factor AP-1,
pubmed-meshheading:9811054-Transcriptional Activation
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pubmed:year |
1998
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pubmed:articleTitle |
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
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pubmed:affiliation |
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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