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rdf:type |
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lifeskim:mentions |
umls-concept:C0007587,
umls-concept:C0019682,
umls-concept:C0019691,
umls-concept:C0019699,
umls-concept:C0022020,
umls-concept:C0033634,
umls-concept:C0041904,
umls-concept:C0048451,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0253023,
umls-concept:C1515370,
umls-concept:C1546857,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
1998-11-23
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pubmed:abstractText |
HIV protein gp120 in combination with T cell antigen receptor (TCR) triggering induces apoptosis (gp120-apoptosis) in Th1 cells. Gp120-apoptosis occurs by induction of Fas-L and subsequent triggering of the Fas apoptotic pathway. Here, through the use of several compounds inhibiting induction of Fas-L, we show that, in a Th1 clone, a protein kinase C (PKC) independent pathway activated by TCR stimulation is distinguishible from a PKC dependent pathway activated by either phorbol 12-myristate 13-acetate (PMA)/ionomycin or asynchronous stimulation of TCR and CD4 as occurs in gp120-apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
436
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
461-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9801169-Antigens, Surface,
pubmed-meshheading:9801169-Apoptosis,
pubmed-meshheading:9801169-Cell Death,
pubmed-meshheading:9801169-Clone Cells,
pubmed-meshheading:9801169-Cyclosporine,
pubmed-meshheading:9801169-Enzyme Inhibitors,
pubmed-meshheading:9801169-Fas Ligand Protein,
pubmed-meshheading:9801169-Gene Expression Regulation,
pubmed-meshheading:9801169-HIV Envelope Protein gp120,
pubmed-meshheading:9801169-Humans,
pubmed-meshheading:9801169-Ionomycin,
pubmed-meshheading:9801169-Kinetics,
pubmed-meshheading:9801169-Lymphocyte Activation,
pubmed-meshheading:9801169-Membrane Glycoproteins,
pubmed-meshheading:9801169-Naphthalenes,
pubmed-meshheading:9801169-Protein Kinase C,
pubmed-meshheading:9801169-Receptors, Antigen, T-Cell,
pubmed-meshheading:9801169-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:9801169-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9801169-Th1 Cells
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pubmed:year |
1998
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pubmed:articleTitle |
HIV/gp120 and PMA/ionomycin induced apoptosis but not activation induced cell death require PKC for Fas-L upregulation.
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pubmed:affiliation |
Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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