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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-12-11
|
| pubmed:abstractText |
The authors studied effects of opioid receptor agonists on neuronal nicotinic-receptor-mediated current in PC12 cells using whole-cell current recording. At 1 microM, [d-Ala, N-Me, Phe, Gly-ol]- enkephalin (DAMGO), a selective micro receptor agonist, or 10 microM methionine-enkephalin, a micro and delta receptor agonist, did not inhibit the current elicited by 30 microM nicotine significantly. Dynorphin A (1-17) (0.1-1 microM), an endogenous kappa receptor agonist, and U50488 (0.1-10 microM), a non-peptide selective kappa receptor agonist, depressed the nicotine-induced current reversibly in a dose-dependent manner. They accelerated the current decay, resulting in greater effects on the non-desensitized current than the peak current. These effects were not affected by nor-binaltrophimine, a selective kappa receptor antagonist, or by inclusion of guanosine 5'-O-(2-thiobiphosphate) (GDP[beta-S]), a GTP binding protein blocker, into the pipette solution. These results demonstrate that two kappa opioid receptor agonists, dynorphin A (1-17) and U50488, inhibit neuronal nicotinic-receptor-mediated current without the involvement of opioid receptors or GTP binding proteins. The acceleration of the current decay suggests a direct action on nicotinic receptors such as open channel block, or augmentation of desensitization. Modulation of neuronal nicotinic receptors by dynorphins may play a role in some areas where dynorphin release sites and neuronal nicotinic receptors are colocalized.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/norbinaltorphimine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0031-6768
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
436
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
887-93
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9799403-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz...,
pubmed-meshheading:9799403-Animals,
pubmed-meshheading:9799403-Dynorphins,
pubmed-meshheading:9799403-Electric Conductivity,
pubmed-meshheading:9799403-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:9799403-Enkephalin, Methionine,
pubmed-meshheading:9799403-Enkephalins,
pubmed-meshheading:9799403-Naltrexone,
pubmed-meshheading:9799403-Narcotic Antagonists,
pubmed-meshheading:9799403-Neurons,
pubmed-meshheading:9799403-Nicotinic Antagonists,
pubmed-meshheading:9799403-PC12 Cells,
pubmed-meshheading:9799403-Rats,
pubmed-meshheading:9799403-Receptors, Nicotinic,
pubmed-meshheading:9799403-Receptors, Opioid, kappa
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
|
| pubmed:affiliation |
Department of Anesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236, Japan.
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| pubmed:publicationType |
Journal Article
|