| pubmed-article:9788434 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C0919496 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C0968902 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C1705552 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9788434 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:9788434 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:9788434 | pubmed:dateCreated | 1998-11-6 | lld:pubmed |
| pubmed-article:9788434 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:abstractText | The AP-2 family of transcription factors (AP-2alpha, AP-2beta and AP-2gamma) is temporally and spatially regulated in mammals and has also been implicated in oncogenesis. Here we report the isolation of genomic and cDNA clones encoding the Drosophila homologue of AP-2, designated DAP-2. The predicted amino acid sequence exhibits 42-45% overall identity with the vertebrate AP-2 proteins. A sequence of 107 amino acids within the DNA binding and dimerization domain of the vertebrate AP-2 proteins is highly conserved (90-92%) with the DAP-2 homologue. An in vitro translation product of DAP-2 cDNA binds specifically to AP-2 consensus binding sites. DAP-2 was also shown to be functionally conserved in vivo because transient transfection of a DAP-2 expression plasmid activated transcription through AP-2 binding sites in both mammalian and Drosophila cell lines. DAP-2 is expressed during early embryogenesis and DAP-2 transcripts are also detected in the adult. Whole-mount in situ hybridizations demonstrated that DAP-2 is expressed initially at stage 9 of Drosophila embryonic development and that DAP-2 transcripts are detected in regions of the brain, eye-antennal disc, optical lobe, antenno-maxillary complex, and in a subset of cells of the ventral nerve cord. The cloning of DAP-2 and the identification of the DAP-2 expression pattern during embryogenesis provides a starting point to address the function of AP-2 during differentiation and development in a well understood model system. | lld:pubmed |
| pubmed-article:9788434 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9788434 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9788434 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9788434 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9788434 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9788434 | pubmed:author | pubmed-author:BauerRR | lld:pubmed |
| pubmed-article:9788434 | pubmed:author | pubmed-author:TainskyM AMA | lld:pubmed |
| pubmed-article:9788434 | pubmed:author | pubmed-author:McGuffinM EME | lld:pubmed |
| pubmed-article:9788434 | pubmed:author | pubmed-author:MattosRR | lld:pubmed |
| pubmed-article:9788434 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9788434 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9788434 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9788434 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9788434 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9788434 | pubmed:pagination | 1911-22 | lld:pubmed |
| pubmed-article:9788434 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:meshHeading | pubmed-meshheading:9788434-... | lld:pubmed |
| pubmed-article:9788434 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9788434 | pubmed:articleTitle | Cloning and characterization of the Drosophila homologue of the AP-2 transcription factor. | lld:pubmed |
| pubmed-article:9788434 | pubmed:affiliation | Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. | lld:pubmed |
| pubmed-article:9788434 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9788434 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9788434 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:40398 | entrezgene:pubmed | pubmed-article:9788434 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9788434 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9788434 | lld:pubmed |
