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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1977-1-3
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pubmed:abstractText |
1. Insulin (1 mu./ml.) potentiated the release of amylase from isolated pancreas of rats perfused with erythrocyte-containing medium and stimulated by 0-5 m-u. pancreozymin (Pz)/ml., whereas the same concentration of insulin failed to potentiate the response evoked by or 200 m-u. PZ/ml. 2. Intracellular measurement of membrane potentials from the acinar cells of the same preparations showed that insulin (1 mu./ml.) simultaneously potentiates the hyperpolarization and amylase release in response to 0-5 m-u. PZ/ml. 3. These effects of insulin on the PZ-induced responses were inhibited by ouabain (3 X 10(-5) M). 4. The results suggest that insulin, in the concentration studied, has a potentiating action on the activity of an electrogenic Na pump, which maintains the hyperpolarization and amylase release during continuous stimulation with Pz. 5. Insulin in also potentiated the Pz-induced amylase release in the rat pancreata in situ after vagotomy and ligature of the pyloric region.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-1142220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-15406435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4183910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4463136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4542575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4558161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4721379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4778143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4876421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-4884553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-5422425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-5438004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-5766909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/978585-966397
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:978585-Amylases,
pubmed-meshheading:978585-Animals,
pubmed-meshheading:978585-Biological Transport, Active,
pubmed-meshheading:978585-Cholecystokinin,
pubmed-meshheading:978585-Drug Synergism,
pubmed-meshheading:978585-Insulin,
pubmed-meshheading:978585-Male,
pubmed-meshheading:978585-Membrane Potentials,
pubmed-meshheading:978585-Ouabain,
pubmed-meshheading:978585-Pancreas,
pubmed-meshheading:978585-Rats,
pubmed-meshheading:978585-Tachyphylaxis
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pubmed:year |
1976
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pubmed:articleTitle |
The potentiating influences of insulin on pancreozymin-induced hyperpolarization and amylase release in the pancreatic acinar cell.
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pubmed:publicationType |
Journal Article,
In Vitro
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