| pubmed-article:9743327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0111208 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0104998 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1366561 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1705431 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C0063356 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1413237 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1423536 | lld:lifeskim |
| pubmed-article:9743327 | lifeskim:mentions | umls-concept:C1522634 | lld:lifeskim |
| pubmed-article:9743327 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9743327 | pubmed:dateCreated | 1998-10-6 | lld:pubmed |
| pubmed-article:9743327 | pubmed:abstractText | The identification of all CD28/CTLA-4 counterreceptors is critical to our understanding of this pivotal pathway of T cell activation. Clouding our understanding has been the reported discrepancies in expression and function of the B7-1 (CD80) molecule based upon the use of the BB1 vs other anti-B7-1 mAbs. To resolve this issue, we have cloned a BB1-binding molecule from the BB1+B7-1(-) NALM-6 pre-B cell line. Here, we demonstrate that this BB1-binding molecule is identical to the cell surface form of CD74 (MHC class II-associated invariant chain). CD74-transfected cells bound the BB1 mAb but not other anti-CD80 mAbs, CD28-Ig, or CTLA4Ig. Absorption and blocking experiments confirmed the reactivity of BB1 mAb with CD74. A region of weak homology was identified between CD74 and the region of B7-1 encoding the BB1 epitope. Therefore, the BB1 mAb binds to a protein distinct from B7-1, and this epitope is also present on the B7-1 protein. Many of the puzzling observations in the literature concerning the expression of human B7-1 are resolved by an understanding that BB1 staining is the summation of CD74 plus B7-1 expression. This observation requires the field to reconsider studies using BB1 mAb in the analysis of CD80 expression and function. | lld:pubmed |
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| pubmed-article:9743327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9743327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9743327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9743327 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9743327 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:NadlerL MLM | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:ClarkE AEA | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:FreemanG JGJ | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:BoussiotisV... | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:GrovesR WRW | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:KupperT STS | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:CardosoA AAA | lld:pubmed |
| pubmed-article:9743327 | pubmed:author | pubmed-author:AnumanthanAA | lld:pubmed |
| pubmed-article:9743327 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9743327 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9743327 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:9743327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9743327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9743327 | pubmed:pagination | 2708-15 | lld:pubmed |
| pubmed-article:9743327 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9743327 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9743327 | pubmed:articleTitle | The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. | lld:pubmed |
| pubmed-article:9743327 | pubmed:affiliation | Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. gordon freeman@macmailgw.dfci.harvard.edu | lld:pubmed |
| pubmed-article:9743327 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9743327 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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