An in vitro model was devised to compare the relative effects of recombinant transforming growth factor-alpha (TGFalpha), aqueous human milk, and human milk macrophage (HMM) medium on human fetal small intestinal cell (FHs-74) proliferation.
The effect of recombinant TGFalpha, human milk, and human milk macrophage media on gut epithelial proliferation is decreased in the presence of a neutralizing TGFalpha antibody.
Department of Pediatrics, Human Milk Lactation Research and Education Center, Children's Hospital, Medical University of South Carolina, Charleston, S.C., USA. wagnercl@musc.edu