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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1998-9-24
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pubmed:abstractText |
Isolated limb perfusion (ILP) with TNFalpha in combination with melphalan and IFNgamma has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFalpha-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the anti-tumor effect of TNFalpha.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-4804
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1998 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9733636-Animals,
pubmed-meshheading:9733636-Extremities,
pubmed-meshheading:9733636-Leukocyte Count,
pubmed-meshheading:9733636-Male,
pubmed-meshheading:9733636-Melphalan,
pubmed-meshheading:9733636-Necrosis,
pubmed-meshheading:9733636-Neovascularization, Pathologic,
pubmed-meshheading:9733636-Neutrophils,
pubmed-meshheading:9733636-Organ Culture Techniques,
pubmed-meshheading:9733636-Platelet Aggregation,
pubmed-meshheading:9733636-Rats,
pubmed-meshheading:9733636-Rats, Inbred BN,
pubmed-meshheading:9733636-Sarcoma, Experimental,
pubmed-meshheading:9733636-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
Assessment of the role of neutrophils on the antitumor effect of TNFalpha in an in vivo isolated limb perfusion model in sarcoma-bearing brown Norway rats.
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pubmed:affiliation |
Department of Surgery, University Hospital Rotterdam-Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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