Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-9-28
pubmed:abstractText
In the developing Drosophila eye, BarH1 and BarH2, paired homeobox genes expressed in R1/R6 outer photoreceptors and primary pigment cells, are essential for normal eye morphogenesis. Here, we show evidence that BarH1 ectopically expressed under the control of the sevenless enhancer (sev-BarH1) causes two types of cone cell transformation: transformation of anterior/posterior cone cells into outer photoreceptors and transformation of equatorial/polar cone cells into primary pigment cells. sev-BarH1repressed the endogenous expression of the rough homeobox gene in R3/R4 photoreceptors, while the BarH2 homeobox gene was activated by sev-BarH1 in an appreciable fraction of extra outer photoreceptors. In primary pigment cells generated by cone cell transformation, the expression of cut, a homeobox gene specific to cone cells, was completely replaced with that of Bar homeobox genes. Extra outer photoreceptor formation was suppressed and enhanced, respectively, by reducing the activity of Ras/MAPK signaling and by dosage reduction of yan, a negative regulator of the pathway, suggesting interactions between Bar homeobox genes (cell fate determinants) and Ras/MAPK signaling in eye development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/B-H1 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/BarH2 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/anterior open protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/sev protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Academic Press.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
200
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-45
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9705222-Animals, pubmed-meshheading:9705222-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9705222-Drosophila, pubmed-meshheading:9705222-Drosophila Proteins, pubmed-meshheading:9705222-Eye Proteins, pubmed-meshheading:9705222-Female, pubmed-meshheading:9705222-Gene Expression Regulation, Developmental, pubmed-meshheading:9705222-Genes, Homeobox, pubmed-meshheading:9705222-Homeodomain Proteins, pubmed-meshheading:9705222-Immunohistochemistry, pubmed-meshheading:9705222-Male, pubmed-meshheading:9705222-Membrane Glycoproteins, pubmed-meshheading:9705222-Morphogenesis, pubmed-meshheading:9705222-Phenotype, pubmed-meshheading:9705222-Photoreceptor Cells, Invertebrate, pubmed-meshheading:9705222-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:9705222-Repressor Proteins, pubmed-meshheading:9705222-Retinal Cone Photoreceptor Cells, pubmed-meshheading:9705222-Transcription Factors
pubmed:year
1998
pubmed:articleTitle
Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye.
pubmed:affiliation
Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't