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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-10-1
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pubmed:abstractText |
The aim of this study was to compare the effect on beta2-microglobulin (beta2-M) plasma levels of dialyzers with 3 low-flux synthetic membranes and regenerated cellulose (Cuprophan) in 12 chronic dialysis patients. The synthetic membrane materials chosen were low-flux polymethylmethacrylate (PMMA), low-flux polysulfone (PS 400), and polycarbonate-polyether (Gambrane). Adequate and comparable removal of small solutes was provided by dialyzers with all 4 membrane materials used under similar conditions. A significant reduction of beta2-M plasma levels was seen only with Gambrane while the other 2 synthetic membrane materials gave rise to increases similar to those known to occur with Cuprophan. After correction for the hemoconcentration caused by ultrafiltration, dialysis with Gambrane showed a 24% lower plasma beta2-M level while the beta2-M concentrations with the other 3 membrane materials were practically unchanged. In addition, the efficiency of Gambrane dialyzers in beta2-M removal was able to significantly lower the predialysis plasma beta2-M levels after only 5 dialysis sessions. The hemocompatibility of the 3 synthetic low-flux membranes as judged by the white blood cell (WBC) count and complement activation was similar and therefore cannot be used to explain the different beta2-M plasma levels. In anticipation of gaining further insight into the mechanisms of accumulation and deposition of beta2-M in dialysis patients, a worthwhile approach may be to use a low-flux membrane such as Gambrane which combines removal with protection against potential activating factors in the dialysis fluid.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anaphylatoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Cellulose,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C3a,
http://linkedlifedata.com/resource/pubmed/chemical/Dialysis Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Membranes, Artificial,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Polymethyl Methacrylate,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Urea,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin,
http://linkedlifedata.com/resource/pubmed/chemical/complement C3a, des-Arg-(77),
http://linkedlifedata.com/resource/pubmed/chemical/cuprammonium cellulose,
http://linkedlifedata.com/resource/pubmed/chemical/polycarbonate-polyether copolymer,
http://linkedlifedata.com/resource/pubmed/chemical/polysulfone P 1700
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0160-564X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9684696-Aged,
pubmed-meshheading:9684696-Analysis of Variance,
pubmed-meshheading:9684696-Anaphylatoxins,
pubmed-meshheading:9684696-Biocompatible Materials,
pubmed-meshheading:9684696-Cellulose,
pubmed-meshheading:9684696-Complement Activation,
pubmed-meshheading:9684696-Complement C3a,
pubmed-meshheading:9684696-Dialysis Solutions,
pubmed-meshheading:9684696-Female,
pubmed-meshheading:9684696-Hemofiltration,
pubmed-meshheading:9684696-Humans,
pubmed-meshheading:9684696-Leukocyte Count,
pubmed-meshheading:9684696-Male,
pubmed-meshheading:9684696-Membranes, Artificial,
pubmed-meshheading:9684696-Phosphates,
pubmed-meshheading:9684696-Polymers,
pubmed-meshheading:9684696-Polymethyl Methacrylate,
pubmed-meshheading:9684696-Renal Dialysis,
pubmed-meshheading:9684696-Sulfones,
pubmed-meshheading:9684696-Urea,
pubmed-meshheading:9684696-beta 2-Microglobulin
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pubmed:year |
1998
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pubmed:articleTitle |
Beta2-microglobulin and low-flux synthetic dialyzers.
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pubmed:affiliation |
International Faculty for Artificial Organs, University of Strathclyde, Glasgow, Scotland.
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pubmed:publicationType |
Journal Article,
Comparative Study
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