Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1998-8-20
pubmed:abstractText
The human beta-globin locus control region (LCR), which consists of four erythroid-specific DNase I hypersensitive sites (HS1-HS4), functions over a long distance to control the transcription, chromatin structure, and replication of the beta-globin genes. We have used stable transfection assays to show that activation of the mitogen-activated protein (MAP) kinase pathway by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate (TPA) induces enhancer activity of the LCR subregion HS2, but not HS3. Although HS2 enhancer activity is diminished with increasing distance from the promoter, the relative level of induction by TPA is independent of HS2-promoter distance. Mutation of cis-elements within HS2 reveals that the tandem-binding sites for the hematopoietic-specific transcription factor NF-E2 are required for induction by TPA, and induction is conferred by expressing NF-E2 in an NF-E2-null cell line. These results show that MAP kinases target factors functioning through the NF-E2 sites to enhance long-range transactivation by the LCR.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-1497310, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-1709381, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-1731219, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2027748, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2046667, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2249769, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2357964, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2357965, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2748594, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-2780563, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-3014651, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-3456593, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-3690667, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-6232614, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-6349795, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-7623856, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-7708685, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-7774011, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-7937919, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8028671, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8036168, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8078893, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8152905, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8206977, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8248256, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8444885, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8464710, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8649367, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8684459, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8887638, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8943307, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-8945521, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9032267, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9067628, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9067635, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9069263, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9114030, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9121442, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9166829, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9171106, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9182527, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9192631, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9287350, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9294161, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9305852, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9398325, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9447975, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9478996, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9482838, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671751-9549755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8756-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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