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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-7-27
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pubmed:abstractText |
Tec29 encodes the only known Drosophila member of the Tec tyrosine kinases. By identifying the first mutations in Tec29 (formerly Src29A), we show that it is essential for head involution during embryogenesis and for ring canal development during oogenesis. Tec29 mutant egg chambers are defective in transfer of cytoplasm from the accessory nurse cells through the ring canals into the oocyte. Growth of the mutant ring canals is arrested, and they lack the strong phosphotyrosine localization seen in wild-type ring canals. Mutants lacking the Drosophila Src homolog Src64 show the same phenotype, and we show that Src64 is required for the localization of Tec29 to the ring canals. This interaction is similar to that between vertebrate Src and Tec kinases and suggests that Tec29 is an effector of Src64 that modifies ring canal components required for growth.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Src64B protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Tec protein-tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/hu li tai shao protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/kel protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
819-29
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9660965-Actins,
pubmed-meshheading:9660965-Animal Structures,
pubmed-meshheading:9660965-Animals,
pubmed-meshheading:9660965-Base Sequence,
pubmed-meshheading:9660965-Calmodulin-Binding Proteins,
pubmed-meshheading:9660965-Carrier Proteins,
pubmed-meshheading:9660965-Drosophila,
pubmed-meshheading:9660965-Drosophila Proteins,
pubmed-meshheading:9660965-Female,
pubmed-meshheading:9660965-Gene Expression Regulation, Developmental,
pubmed-meshheading:9660965-Genes, Insect,
pubmed-meshheading:9660965-Insect Proteins,
pubmed-meshheading:9660965-Microfilament Proteins,
pubmed-meshheading:9660965-Molecular Sequence Data,
pubmed-meshheading:9660965-Mutation,
pubmed-meshheading:9660965-Oocytes,
pubmed-meshheading:9660965-Protein-Tyrosine Kinases,
pubmed-meshheading:9660965-Proto-Oncogene Proteins,
pubmed-meshheading:9660965-Sequence Homology, Amino Acid,
pubmed-meshheading:9660965-Signal Transduction,
pubmed-meshheading:9660965-Vertebrates
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pubmed:year |
1998
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pubmed:articleTitle |
The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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