Linked Life Data

9656483

Source:http://linkedlifedata.com/resource/pubmed/id/9656483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-7-24
pubmed:abstractText
The potential for long-range base pairing between the 5' and 3' ends of mRNA molecules was examined for 134 Drosophila and 204 human sequences collected from the GenBank database. Each sequence was divided into two parts, a 5' sequence taken from the start of the protein-encoding region and a 3' sequence taken from the end of the transcript. The strongest RNA pairing stem between each pair of 5' and 3' sequences was identified and scored using an alignment program modified to incorporate RNA base pairing. The observed pairing scores were then compared with a random distribution of scores generated by aligning each 5' sequence to random permutations of its corresponding 3' sequence. For both the Drosophila and the human mRNAs, the observed pairing scores were significantly biased toward the upper tail of the random distributions, with 61% of the Drosophila sequences and 64% of the human sequences falling within the upper half of the random distributions. This suggests that a pattern of long-range base pairing may be a common feature of eukaryotic mRNAs. We have also analyzed a subset of Drosophila and human mRNAs which show the greatest potential for long-range pairing. The human pairings appear to be stronger and localized to more specific regions near the ends of the mRNA sequence than those of Drosophila.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0737-4038
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
820-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Long-range base pairing in Drosophila and human mRNA sequences.
pubmed:affiliation
Molecular and Cell Biology Program, University of Maryland, College Park, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.